Guitar Hero 5 is a video game which is the fifth main entry in the Guitar Hero series. The game was developed by Neversoft and published by RedOctane and Activision. It was released in North America on September 1, 2009 and will be released internationally during the same month. Similar to the preceding title, Guitar Hero World Tour, Guitar Hero 5 is geared towards playing in a four-person band experience, including lead and bass guitar, drums, and vocals.

The game is available as a standalone title, allowing players to use existing compatible instrument controllers, and as a bundle that provides these controllers. Guitar Hero 5 adds several new features, such as drop-in/drop-out play, bands composed of any combination of available instruments, a Rockfest competitive mode consisting of several various scoring mechanisms, and both song-specific and general Challenges to unlock new avatars, clothing, and other extras in the game. Many of these changes were added to make the game a more social experience, allowing players across a range of skill levels to be able to play cooperatively and competitively against each other both locally and online.

Guitar Hero 5's track list contains 85 songs by 83 separate artists, and like previous Guitar Hero games, several musicians with works in the game have been modeled through motion capture for avatars in the game, including Johnny Cash, Carlos Santana, Shirley Manson, Kurt Cobain, and Matthew Bellamy. The game continues to support the user-created music studio introduced in World Tour through GHTunes, and additional downloadable content for the game will be made available. A majority of existing downloadable tracks from World Tour are forward-compatible with Guitar Hero 5, along with selected tracks from World Tour and Guitar Hero Smash Hits.